University of Edinburgh
Tessa Moses
Room 1.17, Waddington Building
King's Buildings Campus
Edinburgh EH93BF
https://www.ed.ac.uk/biology/research/facilities/edinomics
RRID: RRID:SCR_021838
Agilent 6560 Ion Mobility Quadrupole Time-of-Flight Liquid Chromatography Mass Spectrometer
Quadrupole Time-of-Flight liquid chromatography mass spectrometer that combines chromatography, ion mobility, and mass spectrometry. The system has electrodynamic ion funnel technology and an attractive low field drift tube design. [Product Link]
RRID:SCR_019434
(Equipment No Longer Active At this Facility)
Agilent 7890B GC System
7890 GC System features accurate temperature controls, precise injection systems, and high performance Electronic Pneumatic Control (EPC) modules for good retention time and area count repeatability. [Product Link]
RRID:SCR_019449
Thermo Q Exactive HF Hybrid Quadrupole-Orbitrap Mass Spectrometer
Identify and quantify more proteins, peptides, lipids, glycans and small molecules accurately and in less time with the Thermo Scientific Q Exactive HF hybrid quadrupole-Orbitrap mass spectrometer. The Q Exactive HF system combines a state-of-the-art segmented quadrupole for high-performance precursor ion selection with a high-resolution, accurate-mass (HR/AM) ultra-high-field Orbitrap mass analyzer to deliver a superior combination of scan speed, resolving power, mass accuracy, spectral quality and sensitivity. Identify, quantify and confirm in a single analysis with a single instrument with the Q Exactive HF mass spectrometer. [Product Link]
RRID:SCR_020558
Thermo Triple Quadrupole LC-MS system
Vantage triple quad and Accela UPLC/MS specializes in quantitative work and selective assays of targeted analytes, including metabolites and other small molecules, and peptides from complex matrices such as serum, tissue, cell culture, and other biological sources. [Product Link]
RRID:SCR_020578
Amino Acid Analysis
Assays and Measurements
Automated Liquid Handling
Bioanalytical LC MS/MS
Biochemical Analysis
Consultation
Data Analysis
Data Analysis And Interpretation
Data Processing
Data Processing And Interpretation
Data Visualization
Experimental Design
GC
HPLC
Mass Spectrometry
Mass Spectrometry - Proteins And Peptides
Mass Spectrometry - Small Molecules
Metabolomics
Metabolomics Platform
Natural Product Analysis
Project Management
Proteomics
Proteomics Analysis
Protocol Development
Sample Preparation
Small Molecule Compound Screening
1.) Hopton CM, Nienow P, Cockell CS (2025 Jun 4). Ammonia sets limit to life and alters physiology independently of pH in Halomonas meridiana. Scientific reports, 15(1), 19549. . PMID: 40467658.
2.) P Rigby B, Needham N, Grossi H, Kamenska I, H Campbell I, Meadowcroft B, Creasy F, Fisher C, Bahuguna P, Norrie J, Thompson G, C Gibbs M, Mitchell-Grigorjeva M, McLellan A, Moses T, Burgess K, Brown R, J Thrippleton M, Campbell H, J Smith D, A Simpson S (2025 Jan 21). Pilot study of a ketogenic diet in bipolar disorder: a process evaluation. BMC psychiatry, 25(1), 63. . PMID: 39838365.
3.) Bertolini M, Mendive-Tapia L, Ghashghaei O, Reese A, Lochenie C, Schoepf AM, Sintes M, Tokarczyk K, Nare Z, Scott AD, Knight SR, Aithal AR, Sachdeva A, Lavilla R, Vendrell M (2024 May 22). Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants. ACS central science, 10(5), 969-977. . PMID: 38799658.
4.) Noordally ZB, Hindle MM, Martin SF, Seaton DD, Simpson TI, Le Bihan T, Millar AJ (2023 Sep 29). A phospho-dawn of protein modification anticipates light onset in the picoeukaryote Ostreococcus tauri. Journal of experimental botany, 74(18), 5514-5531. . PMID: 37481465.
5.) Johnston EJ, Tallis J, Cunningham-Oakes E, Moses T, Moore SJ, Hosking S, Rosser SJ (2023 Aug 21). Yeast lacking the sterol C-5 desaturase Erg3 are tolerant to the anti-inflammatory triterpenoid saponin escin. Scientific reports, 13(1), 13617. . PMID: 37604855.
6.) Nare Z, Moses T, Burgess K, Schnaufer A, Walkinshaw MD, Michels PAM (2023). Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes. Frontiers in cellular and infection microbiology, 13(), 1129791. . PMID: 36864883.
7.) Cortada-Garcia J, Haggarty J, Moses T, Daly R, Arnold SA, Burgess K (2022 Oct). On-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process. Biotechnology and bioengineering, 119(10), 2757-2769. . ID: 35798686.
8.) Pičmanová M, Moses T, Cortada-Garcia J, Barrett G, Florance H, Pandor S, Burgess K (2022 Feb 28). Rapid HILIC-Z ion mobility mass spectrometry (RHIMMS) method for untargeted metabolomics of complex biological samples. Metabolomics : Official journal of the Metabolomic Society, 18(3), 16. . ID: 35229219.
9.) Nephali L, Moodley V, Piater L, Steenkamp P, Buthelezi N, Dubery I, Burgess K, Huyser J, Tugizimana F (2021). A Metabolomic Landscape of Maize Plants Treated With a Microbial Biostimulant Under Well-Watered and Drought Conditions. Frontiers in plant science, 12(), 676632. doi: 10.3389/fpls.2021.676632. ID: 34149776.
10.) Myllymäki H, Astorga Johansson J, Grados Porro E, Elliot A, Moses T, Feng Y (2021). Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis. Frontiers in cell and developmental biology, 9(), 684036. doi: 10.3389/fcell.2021.684036. ID: 34414180.
11.) Nephali L, Piater LA, Dubery IA, Patterson V, Huyser J, Burgess K, Tugizimana F (2020 Dec 10). Biostimulants for Plant Growth and Mitigation of Abiotic Stresses: A Metabolomics Perspective. Metabolites, 10(12), . . ID: 33321781.
12.) Johnston EJ, Moses T, Rosser SJ (2020 Jan). The wide-ranging phenotypes of ergosterol biosynthesis mutants, and implications for microbial cell factories. Yeast (Chichester, England), 37(1), 27-44. doi: 10.1002/yea.3452. ID: 31800968.
13.) Dale MP, Moses T, Johnston EJ, Rosser SJ (2020). A systematic comparison of triterpenoid biosynthetic enzymes for the production of oleanolic acid in Saccharomyces cerevisiae. PloS one, 15(5), e0231980. doi: 10.1371/journal.pone.0231980. ID: 32357188.
14.) Vaccaro MC, Alfieri M, De Tommasi N, Moses T, Goossens A, Leone A (2020). Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in <i>S. sclarea</i> Hairy Roots by Engineering the <i>GGPPS</i> and <i>CPPS</i> Genes. Frontiers in plant science, 11(), 924. doi: 10.3389/fpls.2020.00924. ID: 32625231.
15.) Moses T (2019 Nov). WRKY1 Integrates Cellular Nitrogen and Light-Energy Resources in <i>Arabidopsis thaliana</i>. Plant physiology, 181(3), 849-850. . ID: 31685687.
16.) Pollier J, De Geyter N, Moses T, Boachon B, Franco-Zorrilla JM, Bai Y, Lacchini E, Gholami A, Vanden Bossche R, Werck-Reichhart D, Goormachtig S, Goossens A (2019 Aug). The MYB transcription factor Emission of Methyl Anthranilate 1 stimulates emission of methyl anthranilate from Medicago truncatula hairy roots. The Plant journal : for cell and molecular biology, 99(4), 637-654. doi: 10.1111/tpj.14347. ID: 31009122.
17.) Moses T (2019 Mar). Shedding Light on the Power of Light. Plant physiology, 179(3), 775-777. . ID: 30808714.
18.) Almeida A, Dong L, Khakimov B, Bassard JE, Moses T, Lota F, Goossens A, Appendino G, Bak S (2018 Feb). A Single Oxidosqualene Cyclase Produces the <i>Seco</i>-Triterpenoid α-Onocerin. Plant physiology, 176(2), 1469-1484. . ID: 29203557.
We are a small research facility based in the School of Biological Sciences and the Centre for Engineering Biology that provides proteomics and metabolomics services for qualitative and quantitative analysis.
