Children's Hospital of Philadelphia
Lynn Spruce
https://www.research.chop.edu/chop-penn-proteomics-core
RRID: RRID:SCR_023099
1.) Yount TA, Porsch EA, St. Geme JW III (2025 Oct 13). Multi-functional minor pilins coordinate type IV pilus assembly, adherence, motility, and DNA uptake in the pediatric pathogen Kingella kingae mBio, 16(11), e02790-25. . PMCID: 12607826.
2.) Hernandez KA, Porsch EA, Muñoz VL, St. Geme III JW (2025 Sep 2). Identification of a Kingella kingae factor H binding protein that is the major determinant of serum resistance PLOS Pathogens, 21(9), e1013473. . PMCID: 12416846.
3.) Poddar S, Chauvin SD, Archer CH, Qian W, Castillo-Badillo JA, Yin X, Disbennett WM, Miner CA, Holley JA, Naismith TV, Stinson WA, Wei X, Ning Y, Fu J, Ochoa TA, Surve N, Zaver SA, Wodzanowski KA, Balka KR, Venkatraman R, Liu C, Rome K, Bailis W, Shiba Y, Cherry S, Shin S, Semenkovich CF, De Nardo D, Yoh S, Roberson EDO, Chanda SK, Kast DJ, Miner JJ (2025 Mar 20). ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation. Cell, 188(6), 1605-1622.e26. . PMID: 39947179.
4.) Gallagher ER, Oloko PT, Fitch TC, Brown EM, Spruce LA, Holzbaur ELF (2024 Dec 16). Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27. Current biology : CB, 34(24), 5739-5757.e8. . PMID: 39541976.
5.) Palumbos SD, Popolow J, Goldsmith J, Holzbaur EL (2024 Nov 7). Autophagic stress activates distinct compensatory secretory pathways in neurons bioRxiv, (), 2024.11.07.621551. . PMCID: 11580983.
6.) Sundararaman S, Miller J, Daley E, O’Brien K, Kasak P, Daniels A, Edwards R, Heidel K, Bague D, Wilson M, Koelper A, Kourtoglou E, White A, August S, Apple G, Rouamba R, Durand A, Esteb J, Muller F, Johnson R, Hoops G, Dowd C, Odom John A (2024 Aug 31). Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) bioRxiv, (), 2024.08.30.610542. . PMCID: 11383709.
7.) Coscia SM, Moore AS, Thompson CP, Tirrito CF, Ostap EM, Holzbaur EL (2024 May 7). An interphase actin wave promotes mitochondrial content mixing and organelle homeostasis Nature Communications, 15(), 3793. . PMCID: 11076292.
8.) Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM (2023 Nov 4). c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity Nature Communications, 14(), 7098. . PMCID: 10625626.
9.) Lee BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A (2023 Aug 11). Adult human cardiomyocyte mechanics in osteogenesis imperfecta American Journal of Physiology - Heart and Circulatory Physiology, 325(4), H814-H821. . PMCID: 10659261.
Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.
