University of Pennsylvania
502 Stellar-Chance Bldg. Perelman School of Medicine,
University of Pennsylvania, 422 Curie Blvd.
Philadelphia, PA 19104
https://genetics.med.upenn.edu/cores/pgsc/
RRID: RRID:SCR_024999
1.) Moses R, Indeglia A, Levine AS, Hausler R, Kelly G, Miller SA, Anez I, Heller M, Delgado R, Orr C, Kohlmann W, Naumer A, Vagher J, Cahill SR, Maese LD, Karanicolas J, Garber JE, Murphy ME, Maxwell KN (2025 Aug 13). Variation at the R181 residue of p53 confers loss of p53 DNA binding cooperativity with the retention of mitochondrial-associated apoptosis bioRxiv, (), 2025.08.12.669925. . PMCID: 12363861.
2.) Tondi Resta I, Nelson ND, Toorens E, Bleiweiss IJ, Nayak A (2025 Apr 13). Mucinous Cystadenocarcinomas of the Breast Exhibit Heterogeneous Genomic Profile as Triple Negative Breast Cancer, Harbor Alterations in PIK3CA, PTEN, AKT1, and GNAS Genes, and May Not Be Indolent International Journal of Surgical Pathology, 33(7), 1583-1592. . PMCID: 12405650.
3.) Litichevskiy L, Considine M, Gill J, Shandar V, Cox TO, Descamps HC, Wright KM, Amses KR, Dohnalová L, Liou MJ, Tetlak M, Galindo-Fiallos MR, Wong AC, Lundgren P, Kim J, Uhr GT, Rahman RJ, Mason S, Merenstein C, Bushman FD, Raj A, Harding F, Chen Z, Prateek GV, Mullis M, Deighan AG, Robinson L, Tanes C, Bittinger K, Chakraborty M, Bhatt AS, Li H, Barnett I, Davenport ER, Broman KW, Levy M, Cohen RL, Botstein D, Freund A, Di Francesco A, Churchill GA, Li M, Thaiss CA (2025 Mar 31). Gut metagenomes reveal interactions between dietary restriction, aging, and the microbiome in genetically diverse mice Nature microbiology, 10(5), 1240-1257. . PMCID: 12360852.
The core's services include molecular profiling of DNA and RNA on different platforms, Sanger sequencing, full service Next Generation Sequencing with different applications and bioinformatics, fragment analysis including human cell line authentication.
