Northwestern University

Contact Info:

Neil Kelleher

710 N. Fairbanks Ct.

8305 Olson

Chicago, IL 60611

http://proteomics.northwestern.edu/collaborate

Grants and Identifiers:

RRID: RRID:SCR_017945

Instrumentation:

Services Provided:

Relevant Publications:

1.) Murmann AE, Ebadi M, Patel M, Ewe A, Barajas S, Xiao S, Ko MJ, Lee S, Cai W, Paudel B, Sun L, Bartom ET, Kocherginsky M, Liu Y, Kim DH, Aigner A, Peter ME (2026 Jun 16). Developing a pan cancer therapy based on DISE-inducing short RNAs. Molecular Therapy. Nucleic Acids, 37(2), . . PMCID: 13267560.

2.) Hebron DP, Shriver TJ, Ziarek JJ, Rosenzweig AC (2026 May 5). Bis-hydroxylation of Homocitrulline Catalyzed by a Multinuclear Nonheme Iron-Dependent Oxidative Enzyme during RiPP Biosynthesis. bioRxiv : the preprint server for biology, (), . . PMCID: 13174530.

3.) Kaweesa EN, Benson N, Wilson TA, Addo EM, Miglo J, Bazioli JM, Lantvit DD, Agarwal G, Kinghorn AD, Fuchs JR, Burdette JE (2026 Apr 24). Activity of Didesmethylrocaglamide in High Grade Serous Ovarian Cancer Using Preclinical In Vitro and In Vivo Models. Journal of natural products, 89(4), 1161-1173. . PMCID: 13189027.

4.) Yang Y, Wang TY, Fry J, Li Y, Meng Q, Guo Q, Patchen NE, White KH, Ramakrishnan A, Ren Y, Li Q, Zhang X, Ali T, Dawes C, Fragkogianni S, Irvin P, Alam SK, Hoeppner LH, Zhang X, Yee D, Weiner AB, Schaeffer EM, Liu Y, Zhang X, Dehm SM, Cao Q, Yang R (2026 Mar 19). Tumor-specific lncRNA IGF1R-AS1 trans-regulates chromatin interactions associated with oncogenic MYC signaling. Nature communications, 17(1), . . PMCID: 13153188.

5.) Gohil R, Gao Z, Lewis RA, Burkholder NT, Strahl BD, Dowen JM (2026 Jan). HMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription. The Journal of biological chemistry, 302(1), 110997. . PMID: 41325801.

6.) Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Thompson NB, Faull PA, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I (2025 Nov 20). Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle. Molecular cell, 85(22), 4215-4228.e9. . PMCID: 12616479.

7.) Tsui EL, Saunders DC, Lu L, Kennedy T, Lee S, Filip SK, Faull PA, Hunter N, Rowell EE, Gao R, Laronda MM (2025 Sep 24). Primary human ovarian interstitial cells contribute to murine follicle growth through follicle-interstitial paracrine crosstalk Research Square, (), rs.3.rs-7593401. . PMCID: 12486088.

8.) Wang H, Suh F, Fischietti M, Wray B, Filip SK, Faull PA, Hu L, Huang W, Liu B, Platanias LC, Eklund EA (2025 Jul 16). The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response The Journal of Biological Chemistry, 301(8), 110484. . PMCID: 12355552.

9.) Liu Y, Piorczynski TB, Estrella B, Ricker EC, Pazos M, Gonzalez Y, Tolu SS, Ryu Tiger YK, Karan C, Cremers S, Nandakumar R, Honig B, Hwang H, Kelleher NL, Camarillo JM, Abshiru NA, Amengual JE (2025 Mar 15). Targeting Monoallelic CREBBP / EP300 Mutations in Germinal Center-Derived B-Cell Lymphoma with a First-in-Class Histone Acetyltransferase Activator. bioRxiv : the preprint server for biology, (), . . PMID: 40161591.

Description:

Mission The mission of Northwestern Proteomics is to develop new proteomics technologies, to apply them to timely questions in basic, translational and clinical research, and to educate researchers throughout the Chicagoland area and communicate our research findings to the scientific community at large. At Northwestern Proteomics, we're committed to providing the best proteomics research on a budget.  We're scientists first, so we will work with you to review each project as it comes in and offer consultation to ensure that everyone's expectations are managed.  That way, the experiment that we perform has the best chance for success.  Proteomics is not a simple technique; so we're both a University Research Center and service-oriented core, handling multiple projects large and small. Within the Northwestern Proteomics core facility, we offer multiple types of experiments from simple protein identification to protein quantitation (both relative and absolute).  We also perform both traditional bottom-up proteomics, where proteins are digested with an enzyme prior to analysis and intact, top-down proteomics analyses.  The ability to perform top-down proteomics within our core facility distinguishes from many other proteomics cores across the world. How do you start work with us?  If it’s your first time performing proteomics, we should sit down and chat about your system and the questions that you want to answer.  The diversity of method for proteomics can be overwhelming and we’re happy to help narrow down the best experiment for you.  The first step is to go to our Northwestern Proteomics website (http://proteomics.northwestern.edu) and submit a Collaboration Request.  Someone will be in touch to schedule an in-person or telephone conference. If you’ve worked with us before and already know what you want, head over to our Northwestern Proteomics website and fill out a Sample Submission Form.  Once that’s completed, drop off your sample at either of our dropoff locations Monday through Thursday 8:30-5:00pm and Friday 8:30-12:00pm.  Drop Off Locations             Chicago: Olson 8305            Evanston: Silverman B550