The Molecular Interactions and Imaging Core (MIIC) enables research projects by offering support on numerous methodologies to characterize biomolecular interactions. In particular, we provide expertise on sample preparation (working with our sister core bioMT MTC), data collection, and analysis for a range of instrumentation including surface plasmon resonance (label-free analysis of biomolecular interactions) and numerous measurements using absorbance, luminescence, and fluorescence (fluorescence anisotropy, alpha-screen, near-infrared fluorescence)

The Molecular Tools Core is a bioMT and Dartmouth community resource that supports research programs via production of high quality recombinant proteins. The MTC works closely with investigators assisting with the decision-making process, providing expert advice and necessary training on construct design, host selection, optimization of expression conditions and development of purification schemes. The MTC also makes equipment available to the community and trains researchers to produce recombinant proteins in our facility.

Core facility that provides the following services: Tissue collection, Histology services, Molecular pathology services, Pathologist consultation.

The Pathology Shared Resource (PSR) provides four primary services for NCCC investigators: # it partners researchers with appropriate pathologists to provide specific expertise matched to the needs of the research project; # it coordinates the procurement, preservation, and distribution of human tissues and cells for funded and developmental NCCC basic and clinical research; # it performs histologic, immunohistologic, and molecular diagnostic procedures including DNA sequencing SNP genotyping and quantitative gene expression analysis for NCCC researchers; and # it provides a GMP cell processing laboratory for the isolation/purification, manipulation, expansion and/or storage of cells derived from a patient''s/subject''s peripheral blood intended for autologous reinfusion. The Pathology Shared Resource is closely integrated with the anatomic pathology laboratory of Mary Hitchcock Memorial Hospital and provides a cost-effective mechanism for NCCC investigators to take advantage of the economic efficiencies provided by that high-volume facility. The Core is managed by the Norris Cotton Cancer Center as a shared resource on behalf of the university and is available to all investigators within the greater Dartmouth research community. This Shared Resource is supported by funds from the Norris Cotton Cancer Center Core Grant and is overseen by the EMTG, an oversight and advisory committee of the Cancer Center.

Analysis of elemental composition of biological tissues and fluids by Inductively Coupled Plasma Mass spectrometry. Analysis of Arsenic species in urine and blood by chromatography-ICP-MS. Laser ablation analysis of tissue sections for imaging of elemental distributions.

Light microscopy imaging core facility located in the Life Sciences Center at Dartmouth College (Hanover, NH). Facility personnel provide training and imaging advice. Imaging instruments available to trained users include: laser scanning and spinning disk confocal systems (with super-resolution), a TIRF system, and a multiphoton microscope. Image analysis software (e.g. Nikon Elements, ZEN, Arivis Vision 4D, and Imaris Quant) is also available through the facility.

Dartmouth Electron Microscope Facility facility provides access to scanning (conventional and FEG, ESEM, cryo and EDS, EBSD and direct-write E-beam lithography) and transmission (conventional and FEG and EDS) electron microscopes, scanned probe microscope (AFM), Raman confocal light microscope.
Outside users are welcome.