NYU Langone’s Environmental Exposure and Analytical Chemistry Laboratory is a state-of-the-art facility designed for trace-level analysis of anthropogenic organic chemicals in environmental and biological specimens, offering services to our investigators and the greater scientific community. We specialize in mass spectrometry–based analysis, including targeted and nontargeted methods.The laboratory is capable of quantifying nearly all the organic analytes monitored by the Centers for Disease Control and Prevention (CDC) in the National Health and Nutrition Examination Survey (NHANES) program. Commonly assayed targets include phthalates, bisphenols, per- and polyfluoroalkyl substances (PFAS), glyphosate, organophosphate flame retardants, organophosphate pesticides, and other compound classes at biologically and environmentally relevant concentrations. Our nontargeted analysis workflows are capable of detecting hundreds to thousands of chemical features in a single sample, enabling the identification of unknown organic compounds without a priori target selection.Strong evidence shows that exposures from plastics, pesticides, and other anthropogenic chemicals disrupt endocrine regulation, with health effects extending from early development through adulthood. Building on research led by Prof. Leonardo Trasande and the NYU Center for Investigation of Environmental Hazards, which demonstrated that these exposures contribute to substantial disease burdens, premature mortality, and billions of dollars in healthcare costs, our laboratory operates as a shared resource within NYU Langone's Division of Advanced Research Technologies (DART), which is part of the Office of Science and Research (OSR). We provide precise chemical analysis to support studies on environmental exposures and their health impacts.

The Research Software Engineering (RSE) Core is a resource launched by NYU Langone, based in the Information Technology department in close collaboration with the NYU Grossman School of Medicine. We design, develop, optimize, and customize software to accelerate research.

The Rodent Genetic Engineering Laboratory (RGEL) at NYU Langone Medical applies advanced molecular genetic techniques in rodent models. Experienced at generating novel mutant mouse strains by using gene targeting in embryonic stem cells (ESCs) and by developing novel methods of modifying rodent genomes and assaying genetically modified cells in vivo. Customizes technologies to meet individual project needs, including specialized expertise in use clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) systems and other approaches for direct genome editing in vivo.Services include CRISPR/Cas9,proprietary rapid strain-creation method known as EZ-Mouse Model, tetraploid complementation systems, GEMMs-ESC Speedy Models, regulated gene expression by high-throughput RNA interference assay in mice, safe-harbor knock-in gene editing using Rosa26 and other loci, recombinase-mediated cassette exchange, Inducible Tet-On and Tet-Off Gene Expression Systems, homologous recombination, induced pluripotent stem cells, assisted reproductive technologies, and vitrification systems,production of transgenic mice by pronuclear injection of plasmid DNA or bacterial artificial chromosome DNA and the production of ESC chimeras by blastocyst injection. Production of fully ESC-derived mice by tetraploid complementation, including following, isolating, and manipulating novel ESC lines from existing mouse strains.Offers sperm and embryo cryopreservation and storage technologies for strain preservation and recovery. Highly efficient in vitro fertilization technologies using fresh or cryopreserved sperm are available, facilitating import of novel mouse strains without quarantine and recovery of poorly breeding strains.Offers traditional embryo rederivation technologies for animal import into barrier vivaria through quarantine.