The UR Genomics Research Center (GRC), located at the James P. Wilmot Cancer Institute, provides core laboratory support, technical consultation, assistance with experimental design and data analysis for investigators using high-throughput genomic sequencing, genotyping and gene expression in their research programs.

The URGRC currently provides support for RNA-Seq, ATAC-seq, ChIP-Seq, Single Cell RNA-seq, Spatial Transcriptomics, Exome/Genome sequencing, Whole Genome and Reduced Representation Bisulfite Sequencing (WGBS, RRBS), 16S rRNA Sequencing, Small RNA-Seq, Metatranscriptomics, qRT-PCR, processing of RNA/DNA, as well as custom applications and approaches. Bioinformatic analysis support is also available.

Modern immunological techniques are sophisticated and powerful, and can be applied effectively to many basic and clinical projects. However, it is difficult for any one investigator to become expert in all of these complex techniques and expertise in immunology is typically spread across different Departments. The Human Immunology Center (HIC) within the David H. Smith Center for Vaccine Biology and Immunology has been established to acquire, refine and develop expertise in cutting-edge techniques and to support applications in Human Immunology research. The HIC is designed with capabilities to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology.

The goal and mission of the Center for Pediatric Biomedical Research flow facility is to develop, validate and implement polychromatic flow cytometric protocols to support and enrich the research programs of CPBR faculty. This flow facility will focus on the development of experimental and unique protocols to breach previously unexplored avenues of experimentation with flow cytometry.

Our current instrumentation includes:

(1) a 3-laser (488, 633 and 355 nm) 12-color LSR-II with high throughput sampler system.

(2) a 3-laser (488, 633 and 405 nm) 13-color FACSAria cell sorter with ACDU system. This system is validated for BSL-2 sorting.

(3)a 3-laser (488, 653 and 405 nm) Amnis Imagestream imaging cytometer with extended depth of focus module.

Training, consulting and collaboration with investigators (internal and external)is available.