Mass Spectrometry Proteomics Core provides a broad range of services with beginning-to-end support that includes project evaluation and design, sample processing and biochemical purifications, mass spectrometry measurements, data processing, and bioinformatics analysis performed by the experienced core personnel.

Core provides Untargeted Metabolomics, Untargeted Lipidomics, Targeted Metabolomics, Metabolomics Flux and analysis services.

The Optical Imaging & Vital Microscopy (OiVM) Core provides state-of-the-art instrumentation and cutting-edge imaging/image analysis tools for the research applications of a broad range of Baylor College of Medicine investigators. This core is dedicated to vital and intravital imaging of cellular processes within cells, intact tissue explants, developing embryos and functioning organs within the live animal. Our users are focused on a variety of applications such as understanding cell migration, optimizing angiogenic therapies, how blood flow influences development and cancer, immune cell recruitment, stem cell-niche interactions and cancer metastasis.

We perform mRNA or microRNA in situ hybridization on tissue sections. The ISH is performed on a liquid handling robot that can handle up to 196 slides per experiment and we can develop the signal with chromogenic or fluorescent methods.
We can also assist with rodent dissections and embedding of tissue for local customers, and cryostat sectioning, mRNA probe production and imaging (whole slide scanning) for all customers.

Multiple proteomic platforms. MS based identification of protein complexes and PTMs.
Protein interactomes by BiFC technologies. Protein profiling differential expression by 2D gels and liquid chromatogrpahy, antibody and protein arrays and Luminex beads. Custom baculovirus recombinant protein expression/production and monoclonal antibody development and production.

Provides histology services for Autopsy, Cytology, Renal Pathology and Medical Archives Office within Department of Pathology. In conjunction with Pathology Send Out and Archives divisions, provides histology for clinical trial requests, scientific study or interest involving pathology materials. Services include: Complete routine paraffin histology services, including processing and sectioning; Special stains, including but not limited to carbohydrates, connective tissue, fats, lipids, microorganisms, nuclear elements, pigments, silver techniques; Immunopathology slide preparation techniques;DNA slide preparations; Frozen tissue sections; Oversized tissue processing and sectioning ;Histopathology teaching sets; Customized procedures.Services are provided for both human and animal tissue samples.

Microscopy facility serving Texas Medical Center. Facilitates utilization of advanced light microscopy techniques and quantitative image analysis to advance research programs of McGovern Medical School, UTHealth, and the greater Texas Medical Center. Fluorescence microscopy and image analysis core.

We are a fee-for-service research laboratory providing internal and external users a wide spectrum of electron microscopy (EM) techniques. As part of the Houston Methodist Research Institute Department of Neurology, we routinely process samples related to the peripheral nervous system but can help with the ultrastructural study of many biological samples.