The Genomics & Bioinformatics Core Facility (GBCF) at Notre Dame serves a diverse research community that spans basic biomedical research in human disease, vector disease research, population genomics, and environmental genomics. Utilizing Illumina sequencing, single-cell analysis, and spatial transcriptome analysis, we offer comprehensive solutions designed to acquire data for a broad range of applications including metagenomics, cancer genomics, microbial genomics, transcriptomics, and epigenomics for both model and non-model systems. Applying robust bioinformatics tools and biocomputing resources, we offer guidance and analysis workflows specifically tailored to your needs.

Core supports research in chemistry, biochemistry, molecular biology, engineering and related fields. The MRRC operates six solution-state NMR spectrometers (400 to 800 MHz), a solid-state 300 MHz NMR instrument, and an X-band EPR spectrometer. Most instruments are equipped with sample changers for increased sample throughput.

Core develops and uses gene-targeting technology to investigate pathophysiological roles of genes of blood coagulation, anticoagulation, and fibrinolytic pathways in hemostasis, with associated relevance to embryonic development, cancer, infection, and inflammation.

Home to virtually all laboratory animals. Services include Procurement, Animal care, Breeding, Training,Limited procedures for research.

The Biophysics Instrumentation Core (BIC) Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis.

The NDIIF provides an integrated suite of sophisticated microscopes and imaging stations that enable expert users to address the most complex modern research problems and, equally important, expert staff, including technicians and research specialists, to guide the non-expert users. The facility offers imaging expertise in Electron Microscopy, Optical Microscopy, In Vivo Imaging, and Histology.

The Research Laboratory Core is a regional Service Center that performs high throughput assays for the determination of proteins, peptides, hormones and other biochemical markers in support of preclinical and clinical research studies. The laboratory has the equipment and capacity to perform standard immunoassays as well as multiplexed ELISAs. The Research Laboratory Core provides standardized sample handling that upholds high quality control by, for example, minimizing freeze/thaw cycles. The high volume of assays processed in the lab supports reduced investigator cost through batch analysis of samples and direct manufacturer pricing. Quality control is maintained by including manufacturers’ controls as well as low, medium, and high value in-house controls in each assay.